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The key protease responsible for the processing of the proglucagon peptide into GLP-1 is Psck1/3, which has shown to be upregulated in -cells during hyperglycaemic, hyperlipidemic, or inflammatory conditions to promote glucose-induced glucagon suppression, a compensatory response to a metabolic insult as in type 2 diabetes (205)

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[DOI] [PubMed] [Google Scholar] [49].Vora LK, Sabri AH, McKenna PE, Himawan A, Hutton AR, Detamornrat U, Paredes AJ, Larraeta E, Donnelly RF, Microneedle-based biosensing, Nature Reviews Bioengineering (2023) 118