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Type 2 diabetes (though it's not yet approved for this use) : In the phase 3 ACHIEVE-1 trial, adults with early type 2 diabetes who took orforglipron experienced a drop in their A1C from 8% to 6.5%6.7% after 40 weeks

When they do this, they help protect brain cells in different ways: They help clear out toxic proteins

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Increased activity of endogenous endothelin in patients with type II diabetes mellitus