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Despite the strength in the large cumulative sample size and compilation of data from the statistically robust design of RCTs, one of the major limitations of meta-analysis studies for retinopathy is the lack of standardization in reporting and detecting retinopathy across the included trials
In addition, GLP-1 therapies affect body composition by reducing not only fat mass but also lean mass, a concern that is particularly relevant for at-risk groups such as older patients and those with sarcopenic obesity [[7], [8], [9]]
Because it slows digestion, some of the most commonly reported side effects of Ozempic are gastrointestinal, like nausea, diarrhea, vomiting, and loss of appetite
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