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In Canada, only licensed pharmacies can legally sell prescription drugs, the advisory notes [Source: recalls-rappels.canada.ca/en/alert-recall/thinking-about-buying-glp-1-drugs-ozempic-or-mounjaro-beware-fake-or-unauthorized]

Tirzepatide (brand name Mounjaro) targets GLP-1 and GIP, which affect appetite and blood sugar control

Some patients may be more sensitive to the interaction between alcohol and ACE inhibitors, particularly when first starting therapy or after dose increases

Currently, the government guidelines state that adults "with a weight-related health condition such as hypertension or cardiovascular disease and a Body Mass Index (BMI) of at least 35, or, exceptionally, a BMI of 30, if they meet the criteria for specialist weight management services," may be able to qualify for a Wegovy pen prescription on the NHS

Secondary endpoints include radiological PFS (rPFS), PSA50%, and PSA90% response rates (PSA50 RR, PSA90 RR), adverse events, and OS