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Effects when activated: Stimulate insulin secretion from pancreatic beta cells Inhibit glucagon secretion from pancreatic alpha cells Slow gastric emptying Increase satiety (feeling of fullness) Potential neuroprotective effects in the brain GIP Receptors: Function: GIP (Glucose-dependent Insulinotropic Polypeptide) receptors respond to the hormone GIP

Retatrutide reduced WOMAC pain scores by up to 4.5 points (75.8% improvement) at the 9 mg dose and 4.4 points (74.3% improvement) at the 12 mg dose

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A: The most common side effects are gastrointestinalnausea, vomiting, diarrhea, constipation and abdominal painusually greatest during dose escalation and often improve over time