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Its taken as a once-weekly injection and is approved for both type 2 diabetes and weight management

Glucagon-like peptide-1 (GLP-1) agonists are injectable therapies that exploit endogenous hormonal blood glucose control for people with diabetes

Although the mechanisms leading to a blood pressure decrease during the treatment with GLP-1 agonists have not been fully elucidated it could be the result of an increased sodium and water excretion and/or inhibition of the RAAS activity 14

Meanwhile, just 2.8% of semaglutide users reported any levels of depression that required evaluation by a mental health professional during treatment compared with 4.1% of placebo users

This is a multifunctional receptor with a crucial role in the feeding state response, able to regulate glucose and lipid metabolism, bile acid homeostasis, and liver regeneration [116]