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How these medications cause weight loss when combined is still somewhat of a mystery, but experts theorize that the combo touches the brains reward centers: Bupropion affects the pathways of two neurotransmitters, dopamine and norepinephrine, which are used in brain areas that process appetite and reward, and naltrexone tends to boost and reinforce this effect, Maselli says

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Determining optimal doses for psychiatric indications, balancing efficacy against tolerability and metabolic safety, remains a key priority for future trials [15]

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These drugs offer their own advantages, though, according to lead study researcher Shellsea Portillo Canales