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Approaches for targeting p53 can be summarized as follows: first, compounds such as idasanutlin (RG7388) and RG7112 were developed to prevent degradation of wild-type p53 by blocking p53-MDM2 interactions, 369,370 thus maintaining their ability to suppress tumor formation

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Eat fiber-rich foods to ease constipation

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It's important to consider the broader impact before choosing this option

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