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31,32 The prescribing information from the FDA and the European Medicines Agency mention the possible increased risk of cholelithiasis for exenatide 33,34 and subcutaneous semaglutide 35,36 compared with placebo

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Whilst early results are promising, retatrutide is not approved for clinical use , and any claims about its effects outside of peer-reviewed trial data should be viewed critically

This rise may relate to emerging evidence of its metabolic efficacy and weight loss benefits, which could be influencing prescribing patterns among patients with PCOS (16)

Psychological risks include disordered eating patterns