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Melatonin is involved in regulating insulin secretion, and decreased melatonin secretion at night is associated with increased IR [119]

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Gastaldelli A, Cusi K, Fernndez Land L, Bray R, Brouwers B, Rodrguez (2022) Effect of tirzepatide versus insulin degludec on liver fat content and abdominal adipose tissue in people with type 2 diabetes (SURPASS-3 MRI): a substudy of the randomised, open-label, parallel-group, phase 3 SURPASS-3 trial

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Bydureon (AstraZeneca) is an extended release (ER) formulation of Exenatide that requires only once a week dosing

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