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Lancet 368 , 16961705, doi:10.1016/S0140-6736(06)69705-5 (2006)

Hitting the muscle beneath the subcutaneous layer causes deeper pain

"I'm in a completely different place." What to know about weight gain and semaglutide Medical experts say it's important to remember that semaglutide is intended to be one part of a comprehensive approach to wellness that also includes a healthy diet and exercise

Less Common but Serious Side Effects Some less common but more serious GLP-1 side effects are worth being aware of: Pancreatitis (inflammation of the pancreas) Gallbladder problems (including gallstones) Acute kidney injury (usually as a result of severe dehydration from vomiting or diarrhea) Diabetic retinopathy worsening (particularly in patients with rapid improvement in blood sugar control) Hypoglycemia (when combined with other diabetes medications like sulfonylureas or insulin) All GLP-1 medications also carry a warning regarding a theoretical risk of medullary thyroid carcinoma, based on animal studies

Smaller gauge numbers mean larger needles, so 31 gauge is the finest option and typically the most comfortable