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When we look at the epidemiologic data, we recognize that between 0 and 18 years of age, its probably about 1 to 1 of boys and girls being affected equally

The expression of GLP-1 and/or GLP-1R was found in hypothalamic feeding centers (28, 29), hindbrain matrix (30), the lateral parabrachial nucleus of the posterior nucleus (31), and mesolimbic substrates (3234), etc

NICE guidance (NG28) recommends considering GLP-1 receptor agonists for adults with type 2 diabetes when glycaemic targets are not achieved with other therapies, particularly in those with established cardiovascular disease or at high cardiovascular risk

Eggers test revealed significant publication bias for some outcomes at three months, with no evidence of bias for most outcomes at other time points