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Statistical analysis The sample size for the substudy was calculated to ensure a power of at least 80% for detecting the superiority of any dose (1, 4, 8 or 12 mg) of retatrutide versus placebo in change in relative liver fat by MRIPDFF from baseline to week 24

Appetite regulation : Acts on the hypothalamus to promote satiety and reduce food intake

doi: 10.1001/jamanetworkopen.2024.57349, 128 SainsburyA.HayP

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