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2024 Oct 18;8(11):104486

When a cytokine binds to its corresponding receptor, the receptor-associated JAK is activated

The FDA warns that some patients and health care professionals may look to unapproved versions of GLP-1 (glucagon-like peptide-1 (GLP-1) receptor agonists) drugs for weight loss, potentially exposing consumers to counterfeit or unsafe products

The intravenous route was chosen for administration of the parenteral control since this would ensure greatest reproducibility of entry into the bloodstream, and would match more closely the time course of entry of peptide from the intestine, which is seen to be rapid

Whilst injectable GLP-1 therapies such as semaglutide (Ozempic, Wegovy) and liraglutide (Victoza, Saxenda) are well established in UK clinical practice, transdermal patch formulations represent an emerging area of pharmaceutical development