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Standard dosing has demonstrated metabolic results in large randomized trials, while microdosing operates at exposure levels that have not been formally evaluated in those studies

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In addition, regular physical activity, including a mix of aerobic exercises and strength training, can enhance weight loss outcomes

The Zepbound (tirzepatide) label recommends switching to a non-oral birth control method, or adding a barrier method, for 4 weeks after starting Zepbound and for 4 weeks after each dose increase