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10.1016/j.ejps.2018.07.032

Safety Profile of Combined Metformin and Semaglutide Use Clinical trials and real-world evidence confirm that metformin and semaglutide can be safely prescribed together with no major drug interactions

During this time, adults taking a weight loss drug in clinical trials lost an average of about 10 percent of their starting body weight, and they lost an additional eight percent within 15 months

Studies show that appetite regulation returns to baseline within weeks to months after discontinuation, leading to gradual weight regain in about 50 to 80 percent of patients