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Around the same time, 2,4-dinitrophenol, a compound used in explosive manufacturing, was marketed as a weight loss drug and was subsequently banned by the United States Food and Drug Administration (FDA) due to its narrow therapeutic index and severe adverse effects [9,10]

Al-Aly emphasized that his study also highlighted potential downsides to the medications, including an increased risk of gastrointestinal problems such as nausea, vomiting, diarrhea, and in rare cases paralysis of the stomach

38 Patients were randomised to receive subcutaneous semaglutide 2.4 mg weekly or a placebo for 52 weeks

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