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It has been mentioned many times that current research, both pre-clinical and clinical, is focused around exendin-4 ligands

Indeed, Liraglutide can directly activate anorectic POMC/CART neurons in rodents and thus, indirectly inhibit orexigenic AgRP/NPY neurons in the arcuate nucleus (ARC) to reduce food intake (101)

OXM contains the complete amino acid sequence of glucagon but with the addition of 8 amino acids on the C-terminal known as the intervening peptide [11]

Based on a systematic synthesis of available findings, we conclude that there is considerable support for the neuromodulatory potential of gut-based circulating peptides on reward responses

Novo Nordisk has already submitted an application to the FDA for its high-dose (25 mg) oral semaglutide pill for weight management