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This is thought to explain its greater efficacy compared to semaglutide alone

The STEP 5 two-year trial showed semaglutide remains safe and effective with no loss of efficacy, and there is no known ceiling on safe duration under physician supervision

Chronic high fat diet impairs glucagon like peptide-1 sensitivity in vagal afferents

Monitoring recommendations during the early treatment period include regular self-monitoring of blood glucose, particularly for patients taking insulin or sulfonylureas, as dose adjustments of these medications may be necessary to prevent hypoglycemia

Not every patient responds the same way to GLP-1 medications