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Design In the obesity trial, 338 participants (mean age 48 years, 48% women, mean BMI 37.3 kg/m 2 ) were randomised (2:1:1:1:1:2:2) to retatrutide 1 mg, 4 mg (titration), 4 mg (no titration), 8 mg (slow titration), 8 mg (fast titration), 12 mg or placebo over 48 weeks [45]

Leptin is a hormone released by the body to help maintain normal weight and regulate the balance between food intake and energy use, and researchers have identified leptin resistance as one of the main biological contributors to obesity

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Regular consumption of alcohol can accumulate its negative effects, making it harder to lose weight