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Some experimental evidence indicates that GLP-1 receptor activation might modulate dopaminergic pathways involved in reward processing, which could theoretically affect eating behaviours and potentially mood-related circuits

Inhibition of the cAMP-degrading enzyme phosphodiesterase 4 (PDE4) enhances and sustains these cAMP responses, and disruption of G s or cAMP signalling in AP Glp1r neurons abolishes semaglutide-induced weight loss and downstream brain-wide activation

Genetics 213(4):11451188
It is the first in vivo study to systematically evaluate the effects of repeated SNAC exposure on gut microbiota composition, function, and metabolic outcomes
