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This work is supported by the Sanming Project of Medicine in Shenzhen (Grant Number: SZSM202111003), Shenzhen High-level Hospital Construction Fund, the National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Shenzhen Hospital, the Chinese Academy of Medical Sciences, and Peking Union Medical College (SZ2020MS003)

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Ghrelin has dual roles in osteoclastogenesis: inhibiting osteoclast progenitors locally, but stimulating osteoclastogenesis systemically (19)