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Derek Lowe, writing on science.org, summarized the conundrum eloquently

Indeed, P4HA1 catalyzes the hydroxylation of proline residues into 4-hydroxyproline at the Y position in the Glycine-XY motif of collagen chains stabilizing collagen triple helix [23, 63]

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If you want to understand exactly what's happening at a deeper level, our guide to how strength training protects muscle on GLP-1 medications covers the science and what it means practically