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Methods Narrative review of mechanistic pathways and randomized trials of GLP-1 receptor agonists (GLP-1RA), DPP-4 inhibitors, and newer dual/triple agonists, with targeted updates from recent pivotal programs (SELECT, FLOW, SOUL, SURPASS-CVOT) and emerging oral small-molecule GLP-1R agonists

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Cardiovascular and metabolic side effects should be observed particularly in patients with pre-existing conditions for safe administration

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Gynecomastia vs fat comes down to one key distinction: true glandular breast tissue caused by hormonal imbalance versus soft excess chest fat related to overall weight gain