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This triple mechanism distinguishes retatrutide from existing licensed treatments such as semaglutide (a GLP-1 receptor agonist) or tirzepatide (a dual GLP-1/GIP agonist)

11 Obesity contributes to an inflammatory state through adipokines and various pro-inflammatory cytokines 12 and is associated with higher risks of having active disease, 12 poorer surgical outcomes, 13 and impaired quality of life in IBD

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GLP-1RAs can lead to weight reductions of approximately 9.6% to 17.4% of baseline body weight, which is substantially higher than what is typically achieved with lifestyle modifications alone [92,97]