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The higher overall incidence among females is likely due to the contribution of endometrial, ovarian, and postmenopausal breast cancer, and obesity-related cancers that concern both sexes show a higher incidence in males [128]

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The Study of Tirzepatide (LY3298176) in Participants With Obesity or Overweight (SURMOUNT-1) reported that tirzepatide 5.0 mg over 72 weeks led to at least 5% weight loss in 85% of participants with obesity (without diabetes) vs

Patients may not reach or maintain high doses of medication, potentially leading to the underestimation of treatment benefits in real-world scenarios [34, 35]