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GLP-1 medications are FDA approved but like all medications they come with potential side effects

[DOI] [PubMed] [Google Scholar] 43.Tsapas A, Karagiannis T, Kakotrichi P, et al

Clinical research has shown that, when combined with a reduced-calorie diet and increased physical activity, semaglutide can lead to significant weight loss

Berberine is safe for most adults

In this regard, the setting of clinical trials focusing on the improvement of established hepatic fibrosis after treatment with peptide polyagonists seems to be more rational
