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However, the FDA has expressed concern about some compounded versions of semaglutide using ingredients like semaglutide sodium or acetate, which are not listed on the FDAs approved drug shortage list and haven't been evaluated for safety or efficacy in compounded use

Evidence suggests that activation of inflammatory pathways and endoplasmic reticulum stress contribute to the development of leptin resistance

However, it is crucial to emphasise that any decision to use these medications together must be made by a qualified healthcare professional

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2013;7(4):e3017