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Where appropriate, a metaanalysis was performed using a randomeffects model to synthesise quantitative findings

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PKA phosphorylates the K ATP channels, sensitizing them to ATP and facilitating their closure, thus promoting cell depolarization and opening the VDCC, leading to an increase in intracellular Ca ++ (Bnemann, Gerhardstein, Gao & Hosey, 1999

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In addition to its principal activity in islet cells, ghrelin inhibits gastric secretion and gastrointestinal motility, delays gastric emptying, increases satiety and decreases food intake in gastrointestinal tissues (Laviola et al., 2012) (Figure 1)