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Exendin-4 was also associated with increased clearance of total -syn and pathological pSer129--syn via autophagy in the substantia nigra pars compacta of rats, probably via suppression of the PI3K/Akt/mTOR signaling pathway [44]

The research findings require validation through longitudinal studies, since GLP-1RAs might modify immune pathways in ways that could intensify inflammation for some people [51]

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83: 233240 [DOI] [PubMed] [Google Scholar] 171.Nonaka K, Kakikawa T, Sato A, et al