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Although there is no absolute contraindication to using both medications together, their opposing metabolic effectsparticularly on appetite, weight, and blood glucoserequire careful monitoring and individualised management

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Semaglutide typically produces 1015% weight loss, while tirzepatide achieves 1522% reductions

Thanks to transitional assistance often in the form of bridge programs and denial conversions some Mounjaro patients were able to initiate treatment of the new therapy outside of the usual diabetes treatment progression

Rapid weight loss can be common in the first week or two because cutting carbs depletes glycogen, and each gram of glycogen stores about 3 to 4 grams of water