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Another concern with GLP-1 agonists is the loss of body mass, including fat and skeletal muscle, causing some patients to feel a loss of strength

This regulatory effect is partly mediated via the AMPK/sirtuin-1 (SIRT1) axis, as knockdown of SIRT1 abrogated the lipid-lowering and autophagy-inducing effects of GLP-1RAs, highlighting a crucial role of this pathway in regulating lipid metabolism by facilitating degradation of lipid droplets, thus preventing excessive lipid accumulation (12)

[DOI] [PubMed] [Google Scholar] 18.Wing RR, Shoemaker M, Marcus MDM, McDermott M, Gooding W

GLP-1 medications are often used in patients with chronic kidney disease, and caution is warranted

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