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Additionally, the common use of reninangiotensin-system (RAS) inhibitors in combination with SGLT2i and GLP1-RAs is playing a role in decreasing albuminuria by altering renal pathophysiological mechanisms [46,47]

2020;192:E87591

(1) conclude that the safety profile of the newly available glucagon-like peptide 1 (GLP-1) class of drugs is favorable in comparison to their benefits as therapy, and the class of drugs might be considered as next in line after metformin for treatment for type 2 diabetes

The effect of GLP-1 depends on blood glucose levels since it can only potentiate glucose-stimulated insulin secretion from islet beta cells in the hyperglycemic state rather than in the normal blood glucose state (95, 96)

Researchers also suspect that some amino acids (the building blocks of protein) more efficiently increase GLP-1 than others, as demonstrated in one animal model