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The risk of yo-yo effects, where patients lose muscle on the drug and regain fat after stopping, is a real concern

Commercializing CagriSema, if approved, could be challenging

Future competitors will have to clear a high bar to challenge todays leading two players, possibly delivering weight reduction of 20% or more while demonstrating beneficial cardiovascular outcomes

GLP-1 therapies can also cause gastrointestinal adverse effects

Before starting an antipsychotic medication, patients considered high risk for glaucoma or elevated IOP should be screened by an eye doctor
