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These methods allow CUR to bypass first-pass metabolism, thereby delivering higher local concentrations with reduced systemic side effects
cAMP activates PKA, which in turn activates MAPK/ERK anti-inflammatory signaling and also activates and phosphorylates the transcription factor CREB (Jolivalt et al

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At maintenance dose (1015 mg): RM1,8003,000/month plus periodic monitoring

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