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In GF mice and in antibiotic-treated mice, which have a very depleted gut microbiota, enteric neuron number and activation are reduced 72,246,247 , likely via impairments in Toll-like receptor 4 (TLR4) signaling

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Unfolded protein response and PERK kinase as a new therapeutic target in the pathogenesis of Alzheimers disease

Human trials are underway to test their use in Parkinsons and cognitive decline

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