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Management strategies that keep you on track Slow your titration: Extending each dose level from 4 to 68 weeks before escalating gives the GI tract more adaptation time

doi: 10.2337/dc18-2028 [DOI] [PMC free article] [PubMed] [Google Scholar] 56

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Some antibiotics require rapid absorption for therapeutic effectiveness, while others are less time-sensitive

Essential Monitoring and Patient Counseling: If combination therapy is pursued, providers should ensure: Close monitoring for gastrointestinal tolerability Vitamin supplementation (multivitamin with fat-soluble vitamins taken 2 hours from orlistat) Clear instructions on timing (orlistat with fat-containing meals, skip if meal is skipped or fat-free