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Gastrointestinal effects, such as the sensation of prolonged fullness after meals, similarly begin to fade within this timeframe as gastric emptying returns to normal rates

Semaglutide also has other effects beyond insulin secretion

A 12-week snapshot may underestimate the full effect of a given dose, whereas the 48-week results highlight just how powerful extended maintenance can be
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Common adverse effects include gastrointestinal symptoms such as nausea, vomiting, diarrhoea, and constipation, particularly when initiating treatment or increasing the dose
