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These distinct mechanisms mean the two drugs target hunger through fundamentally different biological routes

Bonaventura A et al (2021) Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19

2011 sitaglipitin/simvastatin is now available as a combination product

The glucagon signal can change physical hunger, thermogenesis, and output demand at the same time

While not yet approved, early data suggests even greater weight loss potential than tirzepatide

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