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A new oral GLP-1 therapy, orforglipron (Foundayo) by Eli Lilly and Company, has received US FDA approval, marking a major step forward in accessible weight-management solutions and intensifying competition with Novo Nordisk

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This, in turn, stimulates downstream signaling elements dependent on both protein kinase A (PKA) and exchange protein directly activated by cAMP (EPAC) activation, which triggers the opening of voltage-dependent calcium channels (VDCCs), resulting in insulin exocytosis [24, 25]

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