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Inaccurate dosing

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Direct effects of GLP-1 include the inhibition of glucagon and somatostatin secretion, resulting in suppressed hepatic glucose production and potentiated insulin release, respectively [42], [43], [44]

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ADA Standards of Care 2025) recommend that patients with type 2 diabetes and atherosclerotic cardiovascular disease (ASCVD) (or high risk) should be on a GLP-1 RA with proven CV benefit (or an SGLT2 inhibitor) as part of their regimen, independent of A1c, because of the outcome benefits ( [9] ) ( [144] )