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Recent clinical trials investigating cardiovascular (CV) safety of newer antidiabetic agents have been rapidly and largely changing the landscape of diabetes care and providing highly important clinical information on decision-making regarding the choice of antidiabetic agents

![Figure][1] ### Competing Interest Statement The authors have declared no competing interest

Dipeptidyl-peptidase 4 (DPP4) is a glycoprotein of 110kDa, which is ubiquitously expressed on the surface of a variety of cells

There 9 types of antidiabetic drugs, of which GLP-1RAs are the most popular, find the evolution of GLP-1RAs and their challenges and solutions,

In the U.S., about 75% of adults are overweight or obese. Children arent spared