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Fortunately, several other strategies address the same underlying problems, including plateaus, side effects, and tolerance, without the complexity of medication cycling

The slight yellow coloration comes from the peptide itself and minor variations in manufacturing batches

One consideration for people with a larger thigh circumference is needle length

The 20.9% mean reduction at 72 weeks exceeds the 14.9% (or 18.7% in completers) seen with survodutide at 46 weeks

Last reviewed: July 12, 2026 Last updated: July 12, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations