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Both studies examined the effect of GLP-1RA on fibroblast-like synoviocytes (FLSs), cells in the synovial fluid of joints that normally play a protective and homeostatic role in joint function but can transform into a pathological phenotype that is apoptosis-resistant and proinflammatory in function in the presence of inflammatory stimuli

43 Similarly, Zhong et al (2007) identified GIPRs on murine osteoclasts, suggesting an important and direct impact of GIP in both the formation and breakdown of bone tissue

If youre taking a GLP-1 drug as a treatment for obesity, you may already be aware of this

Thats not incremental