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Some people notice a slight decrease in appetite

What do we know in terms of metabolism

While semaglutide provides substantial metabolic benefits, its GI AEs, most notably nausea, vomiting, diarrhoea, and constipation, can compromise treatment adherence, particularly during the early dose-escalation phase

Compared to placebo, patients receiving retatrutide experienced higher occurrences of nausea, vomiting, decreased appetite, diarrhea, and constipation ( Table 4 )

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