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In men, excess weight contributes to lower testosterone levels, erectile dysfunction, and decreased sexual desire

In isolated intestinal preparations, longchain fatty acids, FFA1 agonists (Christensen et al., 2015), or shortchain fatty acid infusions (Christiansen et al., 2018) into the vasculature, but not the lumen, increase GLP1 levels

Practical Application 12-14 hour overnight fast: Eat between 8am-6pm or 9am-7pm First meal should be protein-rich: Maximizes L-cell response after fasting Last meal 2-3 hours before bed: Supports overnight metabolic processes Maintain consistency: L-cells adapt to regular feeding patterns Important: Time-restricted eating isnt appropriate for everyone

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doi: 10.1210/jc.2011-1954 226 VogelsAMoermanPFrijnsJPBogaertGA