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13.4 Dehydration and Electrolyte Imbalance Risks 13.5 Visual Changes and Diabetic Retinopathy Concerns Rapid improvements in glycemic control may transiently worsen diabetic retinopathy

since hydroxycarbamide is mainly removed from the body by the kidneys, any reduction in kidney function can cause hydroxycarbamide to build up to dangerous levels
Following the standard titration scheduleincreasing by 0.25 mg every four weeksit typically takes 16 to 20 weeks to progress from 0.25 mg to the full 2.4 mg therapeutic dose

A 2 mg vial at the same dose lasts only four weeks

Diabetes Care Standards
