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Electronic databases including PubMed, Embase, and Web of Science were searched from inception until August 2025 using keywords such as GLP-1 receptor agonist, diabetic retinopathy, glaucoma, age-related macular degeneration, ocular disease, and neuroprotection. The search focused on identifying preclinical studies, large-scale retrospective cohort studies, and post-hoc analyses of major clinical trials that evaluated the utility and potential mechanisms of GLP-1RAs in ophthalmic diseases

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Combining bupropion with GLP-1 medications like semaglutide may offer dual benefits for mood and weight management, but understanding potential interactions is essential before starting treatment

The experimental data indicate GLP-1 and its analogs to have direct effects on the cardiovascular system, in addition to their classic glucoregulatory actions

Methods This is a casecontrol observational study in youth with type 2 diabetes who were not on metformin (n=18) compared with youth with NGT (n=10) who were evaluated with a 2 day protocol