half life of glp 1 Exendin-4, but not glucagon-like peptide-1, is cleared exclusively by glomerular filtration in anaesthetised pigs | Diabetologia Designing GLP-1 delivery: structural perspectives

21 GLP-1 and its RA cross the bloodbrain barrier, with exendin-4 considered as one of the best based on the rate of brain influx, percentage of reaching the brain that accumulates in the brain parenchyma, and percentage of the systemic dose taken per gram of brain tissue

Some weight regain during the break is expected and acceptable

Other interactions may exist

Waiting two or more years for an unapproved drug class is rarely the best option for someone who is losing weight and has medical reasons to stay on treatment

They may influence brain pathways involving appetite and mood regulation, including serotonin signaling