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A thorough review of the studies that led to tirzepatides approval allows for comparisons between tirzepatide and GLP-1 RAs

These medications have demonstrated the ability to improve coronary blood flow, reduce acute thrombosis, alleviate I/R-related injury, limit infarct size, and prevent structural and functional remodeling in ischemic hearts
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Osete JR, Akkouh IA, de Assis DR, Szabo A, Frei E, Hughes T, et al

When to Choose Tirzepatide Over Semaglutide: Maximum Weight Loss Needed: If you need to lose 50+ pounds, tirzepatides superior results (5-7% more weight loss) justify the extra cost
